Ntly or sequentially with erythema nodosum [21,405]. The neutrophils are typically locatedNtly or sequentially with

Ntly or sequentially with erythema nodosum [21,405]. The neutrophils are typically located
Ntly or sequentially with erythema nodosum [21,405]. The neutrophils are typically located in the papillary and upper reticular dermis as a dense and diffusely distributed infiltrate in Sweet’s syndrome lesions. However, in some Sweet’s syndrome lesions, the neutrophils have been observed to be perivascular and exhibiting pathologic changes consistent with leukocytoclastic SB856553 web vasculitis [192,193,396,401,410,428]. In these lesions of Sweet’s syndrome, the vascular changes are considered to be those of a “secondary” leukocytoclastic vasculitis occurring as an epiphenomenon and not representative of a “primary” vasculitis [3]. However, some authors have introduced an alternative hypothesis: that Sweet’s syndrome be regarded as a variant of leukocytoclastic vasculitis [428].Behcet’s disease [272] Erythema nodosum [17,30,186,187,190,214,236,264,266,273-276,405,415] Relapsing polychondritis [5,20,195,277-280,409,425] Rheumatoid arthritis [12,16,20,231] PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26240184 Sarcoidosis [18,188,274,281-283,409,413] Thyroid disease: Grave’s disease [117,284,285] and Hashimoto’s thyroiditis [12,286] Source [1]: Adapted with permission from Cohen PR, Kurzrock R: Sweet’s syndrome revisited: a review of disease concepts. Int J Dermatol 2003;42:761?78. Copyright 2003, Reprinted with permission from the International Society of Dermatology, Blackwell Publishing Ltd, Oxford, United Kingdom.Page 11 of(page number not for citation purposes)Orphanet Journal of Rare Diseases 2007, 2:http://www.OJRD.com/content/2/1/Table 7: Conditions for which the validity of their association in Sweet’s syndrome patients remains to be establishedAlpha 1-antitrypsin deficiency [42] Anti-factor VIII inhibitor [287] Antiphospholipid syndrome [1] Aortitis (Takayasu’s arteritis) [286,288] Aplastic anemia [39,99] Autoimmune disorders: autoimmune thrombocytopenic purpura [401], connective tissue disease (undifferentiated) [401], dermatomyositis [20], lupus erythematosus (subacute [289] and systemic [119,290,401]), pemphigus vulgaris [291] and Sjogren’s syndrome [12,17,265,433] Bronchiolitis obliterans and organizing pneumonia [292-294] Chemical fertilizer [158] Chronic fatigue syndrome [295] Cirrhosis (cryptogenic) [30] Cholelithiasis [421] Common bile duct and intrahepatic duct stones [19] Congenital dyserythropoietic anemia [18] Congenital neutropenia (Kostmann’s syndrome) [97] Cutis laxa (acquired, Marshall syndrome) [38,42,245,246] Dressler’s syndrome (postmyocardial infarction syndrome) [17] Eosinophilic granuloma [19] Fanconi anemia [36,241] Glycogen storage disease (Type Ib) [41] Granuloma annulare [296] IgA nephropathy (Berger’s disease) [97] Immunizing agent (BCG vaccination and flu) [17,297,298,419] Immunodeficiency diseases: chronic granulomatous disease [37,299,300], complement deficiency [30], human immunodeficiency virus infection [98,254,302], and primary T-cell immunodeficiency disease [43,303]) Infections: Anaplasma phagocytophilum [304], bartholinitis [17], bronchitis [17], Capnocytophaga canimorsus [305], chlamydia [306-308], cholangitis [19], cholecystitis [12], coccidioidomycosis [309], cytomegalovirus [1,310,311], Entamoeba histolytica [214], Epstein-Barr virus [1], Francisella tularensis [312], Helicobacter pylori [313], hepatitis (acute hepatitis B [314], autoimmune [251], cholestatic [30], chronic active [315], hepatitis C [161], and prior hepatitis A [1]), herpes simplex [316,317], herpes zoster [119], histoplasmosis [259], human immunodeficiency virus [98,254,302], leprosy [1.