Linical and laboratory variables related to mortality in patients with severeLinical and laboratory variables related

Linical and laboratory variables related to mortality in patients with severe
Linical and laboratory variables related to mortality in patients with severe sepsis and septic shockVariable Male gender Age APACHE II score SOFA score Fluid balance (24 hours) Fluid balance (7 days) Hemodialysis Tachycardia PaO2/FiO2 Vasopressor agent (24 hours) MAP (24 hours) Creatinine Lactate Steroid use Leukopenia NT-pro-BNP PCT Correlation r 0.248 0.309 0.478 0.572 0.350 0.590 0.548 0.266 0.320 0.445 0.485 0.548 0.375 0.337 0.404 0.269 0.320 P value 0.05 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.05 0.Multivariate analysis of variables order Vorapaxar associated with mortality observed in patients with severe sepsis and septic shock in the ICU/HRTN between April 2011 and October 2012 (n = 72). CI, confidence interval; HR, hazard ratio; MAP, mean arterial pressure.Clinical and laboratory variables related to the mortality observed in patients with severe sepsis and septic shock in the ICU/HRTN between April 2011 and October 2012 (n = 72). Data expressed as Spearman r and P value. MAP, mean arterial pressure; NT-pro-BNP, N-terminal natriuretic peptide; PCT, procalcitonin.the emergency PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26024392 room (ER). The same intensivist team assists all patients in the ER and during ICU permanence. The principal investigator did not perform any orientation or intervention in the treatment of selected patients. Clinical (age, sex, infection focus, fluid balance, hemodialysis, use of corticosteroids, antibiotic therapy, APACHE II, SOFA), laboratory (blood cell counting, lactate, creatinine, bilirubin, glucose, cortisol, NT-proBNP, C-reactive protein (CRP), procalcitonin (PCT), Troponin I), hemodynamic (blood pressure, heart rate, left ventricular systolic function (echocardiography)) and respiratory parameters (respiratory rate, PaO2/FiO2), PEEP and peak inspiratory pressure (PIP)) were analyzed from ICU admission until discharge or death. Echocardiography was performed at 48 hours and on the 10th day after ICU admission. Results: Seventy-two patients (64 male), mean age 52 ?19 years, were consecutively included, 21 (15/72) with severe sepsis and 79 (57/72) with septic shock. Mortality was 18 (13/72), of these 21 (3/13) for severe sepsis and 79 (10/13) for septic shock. Median APACHE II score was 28 (16 to 37) and SOFA score 6 (5 to 10) (Table 1). There was positive correlation between mortality with: male gender, APACHE II, SOFA, positive 24-hour fluid balance, hemodialysis indication, corticosteroid use, leukopenia, lactate, NT-proBNP and PCT levels (Table 2). From univariate analysis, practically the same significant association with mortality was observed (Table 3). In addition, the final multivariate Cox model showedCritical Care 2013, Volume 17 Suppl 4 http://ccforum.com/supplements/17/SPage 23 ofthat male gender, hypotension (first 24 hours), leukopenia PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25962748 and positive fluid balance (first 24 hours) had an impact on mortality (Table 4). Glycemic control and early antibiotic use were not relevant. Conclusions: Precocious treatment, judicious fluid management and individualized care showed benefit in the treatment of patients with severe sepsis, septic shock.P32 Risk factor for mortality associated with carbapenem-resistant Enterobacteriacea infections Cl dia MDM Carrilho1*, Cintia MC Grion1, Marcos T Tanita1, Jamile Vale1, Larissa Oliveira2, Ana P Marchi2, Silvia F Costa2 1 Universidade Estadual de Londrina, PR, Brazil; 2Universidade de S Paulo, SP, Brazil Critical Care 2013, 17(Suppl 4):P32; doi:10.1186/cc12932 Background: Antimic.