Product Name: Phospho-IRS-1 (Tyr1222) Antibody#3066
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 31431-39-7
Product: Mebendazole
Specificity Sensitivity: Phospho-IRS-1 (Tyr1222) Antibody detects transfected levels of IRS-1 only when phosphorylated at Tyr1222. The antibody may cross-react with other activated receptor tyrosine kinases (RTKs) and docking proteins.
Species Reactivity: Rat
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1222 of human IRS-1. Antibodies are purified by protein A and peptide affinity chromatography.
Background: Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase (1). IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and g
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23287412?dopt=Abstract
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