Product Name: Phospho-Chk1 (Ser345) Antibody#2341
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 101932-71-2
Product: Calyculin A
Specificity Sensitivity: Phospho-Chk1 (Ser345) Antibody detects endogenous levels of Chk1 only when phosphorylated at serine 345. This antibody does not cross-react with Chk1 when phosphorylated at other sites.
Species Reactivity: Human, Mouse, Rat, Monkey
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser345 of human Chk1. Antibodies are purified by protein A and peptide affinity chromatography.
Background: Chk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, embryonic development, and tumor suppression (1). Activation of Chk1 involves phosphorylation at Ser317 and Ser345 by ATM/ATR, followed by autophos
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25370793?dopt=Abstract
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