Product Name: Phospho-cdc25C (Thr48) (D2H3) Rabbit mAb#12028
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:100
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 115103-85-0
Product: MK-571 (sodium salt)
Specificity Sensitivity: Phospho-cdc25C (Thr48) (D2H3) Rabbit mAb recognizes endogenous levels of cdc25C protein only when phosphorylated at Thr48.
Species Reactivity: Human
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr48 of human cdc25C protein.
Background: Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into mitosis (1). cdc25C is constitutively phosphorylated at Ser216 throughout interphase by c-TAK1, while
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24467809?dopt=Abstract
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