Product Name: Phospho-(Ser/Thr) ATM/ATR Substrate (4F7) Rabbit mAb#2909
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 307983-31-9
Product: GRA Ex-25
Specificity Sensitivity: Phospho-(Ser/Thr) ATM/ATR Substrate (4F7) Rabbit mAb detects endogenous levels of proteins containing the ATM/ATR substrate motif. This antibody preferentially binds peptides and proteins that contain phospho-Ser/Thr preceded by Leu or similar hydrophobic
Species Reactivity: All Species Expected
Source Purification: Monoclonal antibody is produced by immunizing animals with synthetic phospho-ATM/ATR substrate peptides.
Background: Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair (1). The identified substrates for ATM are p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/18650380?dopt=Abstract
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