Product Name: ALK (D5F3®) XP® Rabbit mAb#3633
Application: Dilutions
Western Blotting: 1:2000
Immunoprecipitation: 1:100
Immunohistochemistry: 1:250
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 1831167-98-6
Product: DDP-38003 (dihydrochloride)
Specificity Sensitivity: ALK (D5F3®) XP® Rabbit mAb detects endogenous levels of total ALK protein as well as ALK fusion proteins, such as EML4-ALK variants and NPM-ALK, even at low levels. This antibody does not cross-react with other family members.
Species Reactivity: Human
Source Purification: Monoclonal antibody is produced by immunizing animals with recombinant protein corresponding to residues in the carboxy terminus of human ALK.
Background: Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor for pleiotrophin (PTN), a growth factor involved in embryonic brain development (1-3). In ALK-expressing cells, PTN induces phosphorylation of both ALK and the downstream effectors IRS-1, Shc,
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/25601153?dopt=Abstract
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