Product Name: Phospho-Akt (Ser473) (D9W9U) Mouse mAb#12694
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:50
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 73-40-5
Product: Guanine
Specificity Sensitivity: Phospho-Akt (Ser473) (D9W9U) Mouse mAb detects endogenous levels of Akt1 only when phosphorylated at Ser473, Akt2 only when phosphorylated at Ser474 and Akt3 only when phosphorylated at Ser473.
Species Reactivity: Human, Mouse, Rat, Monkey
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues around Ser473 of human Akt1 protein.
Background: Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis (1-3). This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21876120?dopt=Abstract
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