Product Name :
Indacrinone
Description:
Indacrinone (MK196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee.
CAS:
56049-88-8
Molecular Weight:
365.21
Formula:
C18H14Cl2O4
Chemical Name:
2-[(6,7-dichloro-2-methyl-1-oxo-2-phenyl-2,3-dihydro-1H-inden-5-yl)oxy]acetic acid
Smiles :
CC1(CC2=CC(OCC(O)=O)=C(Cl)C(Cl)=C2C1=O)C1C=CC=CC=1
InChiKey:
PRKWVSHZYDOZLP-UHFFFAOYSA-N
InChi :
InChI=1S/C18H14Cl2O4/c1-18(11-5-3-2-4-6-11)8-10-7-12(24-9-13(21)22)15(19)16(20)14(10)17(18)23/h2-7H,8-9H2,1H3,(H,21,22)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Indacrinone (MK196) is an investigational diuretic which has pronounced saluretic activity in the rat and dog as well as both uricosuric and saluretic activity in the chimpanzee.|Product information|CAS Number: 56049-88-8|Molecular Weight: 365.21|Formula: C18H14Cl2O4|Chemical Name: 2-[(6,7-dichloro-2-methyl-1-oxo-2-phenyl-2,3-dihydro-1H-inden-5-yl)oxy]acetic acid|Smiles: CC1(CC2=CC(OCC(O)=O)=C(Cl)C(Cl)=C2C1=O)C1C=CC=CC=1|InChiKey: PRKWVSHZYDOZLP-UHFFFAOYSA-N|InChi: InChI=1S/C18H14Cl2O4/c1-18(11-5-3-2-4-6-11)8-10-7-12(24-9-13(21)22)15(19)16(20)14(10)17(18)23/h2-7H,8-9H2,1H3,(H,21,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Anti-Mouse CD8a Antibody (53-6.7)} web|{Anti-Mouse CD8a Antibody (53-6.7)} Others|{Anti-Mouse CD8a Antibody (53-6.7)} Immunology/Inflammation|{Anti-Mouse CD8a Antibody (53-6.7)} Protocol|{Anti-Mouse CD8a Antibody (53-6.7)} Description|{Anti-Mouse CD8a Antibody (53-6.7)} custom synthesis} |Shelf Life: ≥12 months if stored properly.{{Gemtuzumab} site|{Gemtuzumab} ADC Antibody|{Gemtuzumab} Protocol|{Gemtuzumab} Purity|{Gemtuzumab} manufacturer|{Gemtuzumab} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32907351 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|As the dose increasing from 1 to 10 mg/kg, the amount excreted via the urine decreased from 20 to 11% of administered dose. The amount excretes via the feces is 2-fold higher at the lower dose. At the 10 mg/kg dose the Indacrinone (MK-196)/1 ratio is 0.8 and 5 for the urine and feces, respectively. The urinary ratio of Indacrinone/1 decrease as dose increasing from 10 mg/kg (0.5) to 20 mg/kg (0.2).|Products are for research use only. Not for human use.|
