Product Name :
Manogepix (E1210)
Description:
Manogepix (E1210, MGX, APX001A) is a broad-spectrum and orally active antifungal agent that inhibits Gwt1/Gwt1p (GPI-anchored wall transfer protein 1), a protein that plays an important role in fungal cell wall integrity.
CAS:
936339-60-5
Molecular Weight:
358.39
Formula:
C21H18N4O2
Chemical Name:
(3-(3-(4-(((Pyridin-2-yl)oxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-)amine
Smiles :
NC1=NC=CC=C1C1=CC(CC2=CC=C(COC3=CC=CC=N3)C=C2)=NO1
InChiKey:
WSEKTEUGRLFBSE-UHFFFAOYSA-N
InChi :
InChI=1S/C21H18N4O2/c22-21-18(4-3-11-24-21)19-13-17(25-27-19)12-15-6-8-16(9-7-15)14-26-20-5-1-2-10-23-20/h1-11,13H,12,14H2,(H2,22,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Manogepix (E1210, MGX, APX001A) is a broad-spectrum and orally active antifungal agent that inhibits Gwt1/Gwt1p (GPI-anchored wall transfer protein 1), a protein that plays an important role in fungal cell wall integrity.|Product information|CAS Number: 936339-60-5|Molecular Weight: 358.39|Formula: C21H18N4O2|Synonym:|E-1210|E 1210|APX001A|APX-001-A|APX 001 A|Chemical Name: (3-(3-(4-(((Pyridin-2-yl)oxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-)amine|Smiles: NC1=NC=CC=C1C1=CC(CC2=CC=C(COC3=CC=CC=N3)C=C2)=NO1|InChiKey: WSEKTEUGRLFBSE-UHFFFAOYSA-N|InChi: InChI=1S/C21H18N4O2/c22-21-18(4-3-11-24-21)19-13-17(25-27-19)12-15-6-8-16(9-7-15)14-26-20-5-1-2-10-23-20/h1-11,13H,12,14H2,(H2,22,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 72 mg/mL(200.{{Folinic acid} site|{Folinic acid} Endogenous Metabolite|{Folinic acid} Biological Activity|{Folinic acid} Purity|{Folinic acid} manufacturer|{Folinic acid} Epigenetics} 89 mM).{{CPDA} site|{CPDA} Metabolic Enzyme/Protease|{CPDA} Protocol|{CPDA} In Vitro|{CPDA} custom synthesis|{CPDA} Cancer} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23880095 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Olga Rivero-Menendez, et al. J Antimicrob Chemother. 2019 May 1;74(5):1295-1299.Products are for research use only. Not for human use.|
