Product Name :
TRPV4 agonist-1 free base
Description:
TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay.
CAS:
2314467-59-7
Molecular Weight:
448.46
Formula:
C25H22F2N4O2
Chemical Name:
8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methylpiperazin-1-yl)-3,4-dihydroquinazolin-4-one
Smiles :
CN1CCN(CC1)C1=NC2=C(C=CC=C2F)C(=O)N1C1C=CC(=CC=1)OC1C=CC(F)=CC=1
InChiKey:
NUGPMKZYSBKNPU-UHFFFAOYSA-N
InChi :
InChI=1S/C25H22F2N4O2/c1-29-13-15-30(16-14-29)25-28-23-21(3-2-4-22(23)27)24(32)31(25)18-7-11-20(12-8-18)33-19-9-5-17(26)6-10-19/h2-12H,13-16H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay.|Product information|CAS Number: 2314467-59-7|Molecular Weight: 448.46|Formula: C25H22F2N4O2|Chemical Name: 8-fluoro-3-[4-(4-fluorophenoxy)phenyl]-2-(4-methylpiperazin-1-yl)-3,4-dihydroquinazolin-4-one|Smiles: CN1CCN(CC1)C1=NC2=C(C=CC=C2F)C(=O)N1C1C=CC(=CC=1)OC1C=CC(F)=CC=1|InChiKey: NUGPMKZYSBKNPU-UHFFFAOYSA-N|InChi: InChI=1S/C25H22F2N4O2/c1-29-13-15-30(16-14-29)25-28-23-21(3-2-4-22(23)27)24(32)31(25)18-7-11-20(12-8-18)33-19-9-5-17(26)6-10-19/h2-12H,13-16H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.{{Chymotrypsin} web|{Chymotrypsin} Metabolic Enzyme/Protease|{Chymotrypsin} Biological Activity|{Chymotrypsin} Data Sheet|{Chymotrypsin} manufacturer|{Chymotrypsin} Autophagy} 33 mg/mL (185.{{Naxitamab} site|{Naxitamab} Protocol|{Naxitamab} Formula|{Naxitamab} custom synthesis|{Naxitamab} Epigenetic Reader Domain} 81 mM; Need ultrasonic).PMID:24733396 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels.|Products are for research use only. Not for human use.|
