Product Name :
COH34
Description:
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors.
CAS:
906439-72-3
Molecular Weight:
293.38
Formula:
C18H15NOS
Chemical Name:
1-[(1E)-{[(4-methylphenyl)sulfanyl]imino}methyl]naphthalen-2-ol
Smiles :
CC1C=CC(=CC=1)S/N=C/C1=C(O)C=CC2=CC=CC=C21
InChiKey:
SFUAIBHPGDRCFL-XDHOZWIPSA-N
InChi :
InChI=1S/C18H15NOS/c1-13-6-9-15(10-7-13)21-19-12-17-16-5-3-2-4-14(16)8-11-18(17)20/h2-12,20H,1H3/b19-12+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{BMP-4 Protein, Human} web|{BMP-4 Protein, Human} Technical Information|{BMP-4 Protein, Human} Description|{BMP-4 Protein, Human} manufacturer|{BMP-4 Protein, Human} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.{{Calcitonin salmon} medchemexpress|{Calcitonin salmon} GPCR/G Protein|{Calcitonin salmon} Biological Activity|{Calcitonin salmon} In Vitro|{Calcitonin salmon} supplier|{Calcitonin salmon} Epigenetics} 37 nM.PMID:24670464 COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors.|Product information|CAS Number: 906439-72-3|Molecular Weight: 293.38|Formula: C18H15NOS|Chemical Name: 1-[(1E)-{[(4-methylphenyl)sulfanyl]imino}methyl]naphthalen-2-ol|Smiles: CC1C=CC(=CC=1)S/N=C/C1=C(O)C=CC2=CC=CC=C21|InChiKey: SFUAIBHPGDRCFL-XDHOZWIPSA-N|InChi: InChI=1S/C18H15NOS/c1-13-6-9-15(10-7-13)21-19-12-17-16-5-3-2-4-14(16)8-11-18(17)20/h2-12,20H,1H3/b19-12+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 16.67 mg/mL (56.82 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|COH34 efficiently kills PARP inhibitor-resistant cancer cells.|In Vivo:|COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models.|Products are for research use only. Not for human use.|
