Product Name :
Alstonine
Description:
Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties.
CAS:
642-18-2
Molecular Weight:
348.40
Formula:
C21H20N2O3
Chemical Name:
methyl (15S,16S,20S)-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-1,3,5,7,9,11,18-heptaene-19-carboxylate
Smiles :
C[C@@H]1OC=C([C@H]2CC3=C4N=C5C=CC=CC5=C4C=CN3C[C@@H]12)C(=O)OC
InChiKey:
WYTGDNHDOZPMIW-RCBQFDQVSA-N
InChi :
InChI=1S/C21H20N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-8,11-12,15-16H,9-10H2,1-2H3/t12-,15-,16-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Alstonine is a major indole alkaloid compound of a plant-based remedy.{{G-1} site|{G-1} Estrogen Receptor/ERR|{G-1} Purity & Documentation|{G-1} Formula|{G-1} supplier|{G-1} Cancer} Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties.|Product information|CAS Number: 642-18-2|Molecular Weight: 348.40|Formula: C21H20N2O3|Chemical Name: methyl (15S,16S,20S)-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-1,3,5,7,9,11,18-heptaene-19-carboxylate|Smiles: C[C@@H]1OC=C([C@H]2CC3=C4N=C5C=CC=CC5=C4C=CN3C[C@@H]12)C(=O)OC|InChiKey: WYTGDNHDOZPMIW-RCBQFDQVSA-N|InChi: InChI=1S/C21H20N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-8,11-12,15-16H,9-10H2,1-2H3/t12-,15-,16-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Sitagliptin} web|{Sitagliptin} Autophagy|{Sitagliptin} Technical Information|{Sitagliptin} Data Sheet|{Sitagliptin} manufacturer|{Sitagliptin} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:32926338 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues.|In Vivo:|In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (i.p.) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg. Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages. Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells.|Products are for research use only. Not for human use.|
