Product Name :
Ecopipam
Search keywords :
Hypoxanthine
drugId :
null
Target Vo:
Dopamine D1 receptor
Target Vo Short Name :
DRD1
Moa_Name:
Dopamine D5 receptor antagonists
First Approval Country :
First Approval Date Filter:
null
Origin Company_Name :
Merck Sharp & Dohme Corp
Active Company_Name :
Emalex Biosciences Inc
Active Indication_Name:
Tourette Syndrome
In Active Indication_Name:
Gambling
Termination Status :
China Termination Status :
Highest Status:
Phase 3 Clinical
China Highest Status:
Related websites: https://www.medchemexpress.com/antibodies.html
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eIF5A Antibody
DM4 Antibody (YA3387): Ravtansine (DM4) is a maytansinoid, a chemical derivative of maytansine being investigated as the cytotoxic payload of a number of antibody-drug conjugates (ADCs). Microtubules are dynamic cytoskeletal polymers that switch stochastically between states of growing and shortening, called “dynamic instability”. They function in the precise segregation of chromosomes during cell division, transport of cellular cargos, and positioning and movement of intracellular organelles. Inhibition of microtubule function leads to cell cycle arrest and cell death. Microtubule-targeted drugs including the Vinca alkaloids, taxanes, and epothilones suppress the dynamic instability of microtubules, induce mitotic arrest, inhibit cell proliferation and induce apoptosis. The anticancer properties of maytansinoids have been attributed to their ability to disrupt microtubule function. The maytansinoid emtansine (DM1), for example, binds at the ends of microtubules and thereby suppress their dynamic instability. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death. DM4 can be used in the preparation of antibody drug conjugate. Although S-methyl DM1 and S-methyl DM4 inhibited microtubule assembly more weakly than maytansine, they suppressed dynamic instability more strongly than maytansine. Like vinblastine, the maytansinoids potently suppress microtubule dynamic instability by binding to a small number of high affinity sites, most likely at microtubule ends. Thus, the maytansine derivatives that result from cellular metabolism of the antibody conjugates are themselves potent microtubule poisons, interacting with microtubules as effectively as or more effectively than the parent molecule.
