Tion of hardness, thickness and diameter had been presented (n=10). Study ofTion of hardness, thickness

Tion of hardness, thickness and diameter had been presented (n=10). Study of
Tion of hardness, thickness and diameter had been presented (n=10). Study of water uptake and erosion: As a way to evaluate the water uptake and erosion of each and every tablet, the tablets were individually weighed prior to dissolution testing as original dry weight. Right after dissolution test, every tablet was blotted to get rid of excess water and immediately weighed on analytical balance as wet weight and then all of them had been dried at 60for 24 h and kept in desiccator for at the least 3 days and individually weighed as remaining dry weight. Water uptake and erosion wereMATERIALS AND METHODSHydrochlorothiazide (HCT, batch No I 1413891 was supplied by Government of Pharmaceutical Organization, Thailand). Propranolol HCl (PRO, lot no M080311, Pc Drug Co., Ltd., Bangkok, Thailand), Lutrol F127 (L) (lot no WPDF563B, BASF, Ludwigshafen, Germany) and shellac wax (S) (Ake Shellac Co., Ltd., Lumpang, Thailand) have been made use of as received. Ethylene glycol (lot no.1341646,January – FebruaryIndian Journal of Pharmaceutical Sciencesijpsonlineevaluated gravimetrically in line with the following Eqns., water uptake=(wet weight emaining dry weight)remaining dry weight)00….(Eqn. 1) and erosion=((original dry weight emaining dry weight)original dry weight)00….(Eqn. 2) Determination of contact angle and CRHBP, Human (HEK293, His) surface totally free energy (SFE): Get in touch with angle could describe the wettability of any compound inside the formulation. Moreover, it was utilized to calculate the SFE of these compounds. SFE could be used to describe several properties of compounds like polarity or the miscibility of mixed component [21]. In this experiment, SFE was calculated employing Wu’s Eqn., expressed below.(1 COS ) 1 = four( 1d two d ) 4( 1 p 2 p ) p 1d 2 d 1 2pThe cumulative drug release of PRO or HCT were calculated and plotted against time. The dissolution of combined PRO and HCT matrix tablets were studied using the strategy as previously described. Nevertheless, the quantity of drug release was determined using first derivative UVspectroscopy approach (FUV). Drug release quantity was determined at 297 and 336 nm for PRO and HCT, respectively. The cumulative drug release of PRO and HCT have been calculated and plotted against time. The simultaneous determination of two drugs content was measured with FUV plus the obtained spectra (D1) at 297 and 336 nm for PRO and HCT, Klotho Protein MedChemExpress respectively, was employed for this study. Selection of linearity of PRO and HCT was 1.5-7.five (r 2=0.9999) and 3.6-18.0 ml (r 2=0.9996), respectively. Recovery of PRO and HCT was 106.59 and 97.11, respectively. Precision was determined as intraday and interday precision. The RSD of intraday precision was two.46 and 1.88 for PRO and HCT, respectively. For interday precision, the RSD was 2.23 and 1.57 for PRO and HCT, respectively. LOD of regular curve was found to be 0.10 and 0.49 ml for PRO and HCT, respectively. LOQ was 0.31 and 1.48 ml for PRO and HCT, respectively. Mechanisms of drug release have been evaluated by fitting of cumulative drug release information with mathematical release models. The models applied within this experiment have been zero order, first order, Higuchi’s model, power law expression and Hixson-Crowell cube root equation. The experimental cumulative drug release data inside the array of 10-80 have been employed to evaluate the kinetic of drug release by least square fitting method. The information have been fitted with all the mathematical Eqns by nonlinear computer system programme, Scientist for Windows, version 2.1[22]. The coefficient of determination (r2) was utilized to indicate the degree of.