Eral vein were randomised to get a 20 alanyl-glutamine (Dipeptiven, Fresenius-Kabi) infusion of 0.five

Eral vein were randomised to get a 20 alanyl-glutamine (Dipeptiven, Fresenius-Kabi) infusion of 0.five g/kg or the identical volume of saline for the duration of 4 h in a peripheral vein on three consecutive days. The venous lines (BD Venflon?i.v.; 1.0 mm diameter) had been inserted specially for this purpose, and removed just after every infusion. Unique veins within the identical arm have been made use of. Regional tolerance was evaluated clinically by Maddox score, and ultrasonically (AspenTM Ultrasound Method equipped with L10 transducer with frequency 11? MHz) prior to the infusion and on days 1, 4 and 8 right after the infusion. Results: Inside the study 56 out of 60 (93 ) planned infusions were administered and 157 out of 168 (93 ) clinical evaluations have been successfully performed. The ultrasonic evaluation revealed that the utilized veins had a diameter of two.15 ?0.8 mm (mean ?SD; range 1.0?.4 mm; n = 56) three cm proximal from the insertion web-site. Employing the protocol described above, there had been no signs of thrombophlebitis in any single individuals by either Maddox score or ultrasound. Conclusion: Administration of glutamine-containing dipeptide concentrate (20 ) by peripheral veins is secure in terms of neighborhood tolerance, if a strict protocol is adapted for this goal involving a separate line for the infusion removed right away afterwards.P125 Serum amylin correlates with delayed gastric emptying in critically ill childrenA Mayer, S Skellett, A Durward, SM Tibby, C Turner, N Dalton, IA Murdoch Department Paediatric Intensive Care, Guy’s Hospital, London SE1 9RT, UK Introduction: Delayed gastric emptying is common in critically ill sufferers. Amylin is actually a novel 37 amino acid polypeptide, which can be co-localised and cosecreted with insulin by pancreatic beta cells [1]. In conjunction with its role in glucose homeostasis it really is a potent inhibitor of gastric motility [2]. As a result we hypothesised that high circulating levels of amylin may be associated with delayed gastric emptying PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20718733 in critically ill youngsters.SCritical CareVol 5 Suppl21st International RAF709 chemical information Symposium on Intensive Care and Emergency MedicineMethod: Nineteen kids were enrolled inside 48 hours of ICU admission. Exclusion criteria integrated: liver illness, gastrointestinal abnormalities and use of prokinetic agents. All individuals have been N.P.O., and maintained on a ivi glucose (five? mg/kg/min). Gastric emptying (GE) was assessed clinically by feed intolerance and applying a paracetamol absorption technique (PTA). Feed intolerance was defined as a residual gastric volume > 0.25 ml/kg following 4 hours of a bolus two ml/kg test milk feed. At this point (T0), a single 15 mg/kg dose of paracetamol was administered nasogastrically, and serial blood samples taken for paracetamol assay at 0, 15, 30, 60, 120, 240 and 360 min. GE was calculated applying the gastric emptying ratio (GER) which is the time to reach peak paracetamol level divided by its peak concentration, with higher values reflecting delayed gastric emptying [3]. Blood amylin and insulin sample were taken at T0 and T360 using the imply of these two values used to reflect the typical level over the study period. Amylin was measured by radioimmunoassay. Information had been assumed non-parametric, hence Spearman’s correlation coefficient and Mann hitney tests have been employed. Data are shown as median (interquartile range).Results: Nineteen patients were enrolled having a median age six years (1.7?.five), and weight 20 kg (11.five?1.five). Diagnoses included sepsis (n = 8), respiratory (n = five), head injury (n = 2), neurology (n = two) and also other (n = 2).