Product Name :
AZD2906
Description:
AZD2906 is a selective glucocorticoid receptor (GR) agonist, increases micronucleated immature erythrocytes in the bone marrow of rats. AZD2906 shows IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively.
CAS:
1034148-15-6
Molecular Weight:
460.50
Formula:
C26H25FN4O3
Chemical Name:
N-[(1R,2S)-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide
Smiles :
C[C@H](NC(=O)C1CC1)[C@H](OC1=CC=C2C(C=NN2C2=CC=C(F)C=C2)=C1)C1=CC=C(N=C1)OC
InChiKey:
YDRQCGICZKAGCQ-LMKMVOKYSA-N
InChi :
InChI=1S/C26H25FN4O3/c1-16(30-26(32)17-3-4-17)25(18-5-12-24(33-2)28-14-18)34-22-10-11-23-19(13-22)15-29-31(23)21-8-6-20(27)7-9-21/h5-17,25H,3-4H2,1-2H3,(H,30,32)/t16-,25-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.Dalfopristin In Vitro
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.tert-Butyl 2,2,2-trichloroacetimidate manufacturer
Additional information:
AZD2906 is a selective glucocorticoid receptor (GR) agonist, increases micronucleated immature erythrocytes in the bone marrow of rats.PMID:32981709 AZD2906 shows IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively.|Product information|CAS Number: 1034148-15-6|Molecular Weight: 460.50|Formula: C26H25FN4O3|Chemical Name: N-[(1R,2S)-1-[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide|Smiles: C[C@H](NC(=O)C1CC1)[C@H](OC1=CC=C2C(C=NN2C2=CC=C(F)C=C2)=C1)C1=CC=C(N=C1)OC|InChiKey: YDRQCGICZKAGCQ-LMKMVOKYSA-N|InChi: InChI=1S/C26H25FN4O3/c1-16(30-26(32)17-3-4-17)25(18-5-12-24(33-2)28-14-18)34-22-10-11-23-19(13-22)15-29-31(23)21-8-6-20(27)7-9-21/h5-17,25H,3-4H2,1-2H3,(H,30,32)/t16-,25-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (271.44 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AZD2906 is a selective glucocorticoid receptor (GR), with IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively.|In Vivo:|AZD2906 (5, 25, 50 mg/kg, p.o.) increases micronucleated immature erythrocytes (MIE) in the bone marrow of rats after treatment for 2 days. AZD2906 (5, 25 mg/kg, p.o.) induces an accumulation of glycogen in the liver of rats, and exhibits cortical lymphocytic atrophy of a moderate to marked degree in the thymus of rats.|Products are for research use only. Not for human use.|
