Product Name :
Nemorexant
Description:
Nemorexant (ACT-541468) is a potent orexin receptor antagonist extracted from patent WO2015083094A1, compound example 7, has IC50s of 2 nM and 3 nM for Ox1 receptor and Ox2 receptor, respectively.
CAS:
1505484-82-1
Molecular Weight:
450.92
Formula:
C23H23ClN6O2
Chemical Name:
6-chloro-2-[(2S)-1-[5-methoxy-2-(2H-1,2,3-triazol-2-yl)benzoyl]-2-methylpyrrolidin-2-yl]-7-methyl-1H-1,3-benzodiazole
Smiles :
CC1C(Cl)=CC=C2N=C(NC=12)[C@]1(C)CCCN1C(=O)C1C=C(C=CC=1N1N=CC=N1)OC
InChiKey:
NBGABHGMJVIVBW-QHCPKHFHSA-N
InChi :
InChI=1S/C23H23ClN6O2/c1-14-17(24)6-7-18-20(14)28-22(27-18)23(2)9-4-12-29(23)21(31)16-13-15(32-3)5-8-19(16)30-25-10-11-26-30/h5-8,10-11,13H,4,9,12H2,1-3H3,(H,27,28)/t23-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.Dihydrotachysterol Activator
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Nisin site
Additional information:
Nemorexant (ACT-541468) is a potent orexin receptor antagonist extracted from patent WO2015083094A1, compound example 7, has IC50s of 2 nM and 3 nM for Ox1 receptor and Ox2 receptor, respectively.PMID:32495678 |Product information|CAS Number: 1505484-82-1|Molecular Weight: 450.92|Formula: C23H23ClN6O2|Chemical Name: 6-chloro-2-[(2S)-1-[5-methoxy-2-(2H-1,2,3-triazol-2-yl)benzoyl]-2-methylpyrrolidin-2-yl]-7-methyl-1H-1,3-benzodiazole|Smiles: CC1C(Cl)=CC=C2N=C(NC=12)[C@]1(C)CCCN1C(=O)C1C=C(C=CC=1N1N=CC=N1)OC|InChiKey: NBGABHGMJVIVBW-QHCPKHFHSA-N|InChi: InChI=1S/C23H23ClN6O2/c1-14-17(24)6-7-18-20(14)28-22(27-18)23(2)9-4-12-29(23)21(31)16-13-15(32-3)5-8-19(16)30-25-10-11-26-30/h5-8,10-11,13H,4,9,12H2,1-3H3,(H,27,28)/t23-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 250 mg/mL (554.42 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Nemorexant (Compound example 7) is a orexin receptor antagonist with IC50s of 2 nM and 3 nM for Ox1 receptor and Ox2 receptor, respectively.|Products are for research use only. Not for human use.|
