Product Name :
Troglitazone
Sequence:
Purity:
≥98% (HPLC)
Molecular Weight:
441.5
Solubility :
Soluble in DMSO (>25mg/ml), 100% ethanol (>25mg/ml, warm) or dimethyl formamide.
Appearance:
White to yellow solid.
Use/Stability :
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.1217457-86-7 Purity & Documentation
Description:
PPAR ligand Antidiabetic thiazolidinedione. Potent and selective PPARγ ligand. Binds to the PPARγ ligand-binding domain and recruits ligand-specific transcriptional coactivators at 1µM. In skeletal muscle and adipocyte cell cultures, the EC50 of troglitazone is about 10µM. Displaces [125I]SB-236636 with an IC50=7.9µM. Stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. Induces apoptosis in human vascular smooth muscle cells and inhibits the growth of a variety of human cancer cells including lung, bladder and myeloid leukemia cells. Displays an anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.
CAS :
97322-87-7
Solubility:
Soluble in DMSO (>25mg/ml), 100% ethanol (>25mg/ml, warm) or dimethyl formamide.
Formula:
C24H27NO5S
Additional Information :
| Alternative Name (±)-5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione | Appearance White to yellow solid.852808-04-9 supplier | CAS 97322-87-7 | Couple Target PPAR | Couple Type Ligand | Formula C24H27NO5S | MI 14: 9769 | MW 441.PMID:31424800 5 | Purity ≥98% (HPLC) | RTECS XJ5813130 | Solubility Soluble in DMSO (>25mg/ml), 100% ethanol (>25mg/ml, warm) or dimethyl formamide. | Source Synthetic. | Technical Info / Product Notes Troglitazone is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, troglitazone should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Troglitazone has a solubility of 100µg/ml in a 1:6 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.Note: Product is not sterile. | Unit of Measure (UM) mg
