Product Name :
Acacetin
Description:
Acacetin (5, 7-Dihydroxy-4′-methoxyflavone) is an orally active flavonoid derived from Tephroseris kirilowii (Turcz.) Holub. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research.
CAS:
480-44-4
Molecular Weight:
284.26
Formula:
C16H12O5
Chemical Name:
5, 7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
Smiles :
COC1=CC=C(C=C1)C1=CC(=O)C2=C(C=C(O)C=C2O)O1
InChiKey:
DANYIYRPLHHOCZ-UHFFFAOYSA-N
InChi :
InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Acacetin (5, 7-Dihydroxy-4′-methoxyflavone) is an orally active flavonoid derived from Tephroseris kirilowii (Turcz.) Holub. Acacetin docks in the ATP binding pocket of PI3Kγ. Acacetin causes cell cycle arrest and induces apoptosis and autophagy in cancer cells. Acacetin has potent anti-cancer and anti-inflammatory activity and has the potential for pain-related diseases research.{{Fmoc-Asp(OtBu)-OH} MedChemExpress|{Fmoc-Asp(OtBu)-OH} {Amino Acid Derivatives}|{Fmoc-Asp(OtBu)-OH} Immunology/Inflammation|{Fmoc-Asp(OtBu)-OH} Protocol|{Fmoc-Asp(OtBu)-OH} In stock|{Fmoc-Asp(OtBu)-OH} supplier} |Product information|CAS Number: 480-44-4|Molecular Weight: 284.{{Valbenazine} MedChemExpress|{Valbenazine} Monoamine Transporter|{Valbenazine} Protocol|{Valbenazine} Formula|{Valbenazine} supplier|{Valbenazine} Autophagy} 26|Formula: C16H12O5|Synonym:|5,7-Dihydroxy-4′-methoxyflavone|Chemical Name: 5, 7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one|Smiles: COC1=CC=C(C=C1)C1=CC(=O)C2=C(C=C(O)C=C2O)O1|InChiKey: DANYIYRPLHHOCZ-UHFFFAOYSA-N|InChi: InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 37 mg/mL (130.PMID:32762424 16 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Acacetin (5, 7-Dihydroxy-4′-methoxyflavone; 10-200 μM; 24 hours) decreases cell viabilities in a dose-dependent manner. Acacetin has little effect on human normal glial cell line HEB and non-tumorigenic epithelial cell line MCF-10A. Acacetin (50-150 μM; 24 hours) causes G2/M cell cycle arrest and induces apoptosis and autophagy. Acacetin (50-150 μM; 24 hours) leads to decreases in levels of PI3Kγ-p110, p-AKT, p-mTOR, p-p70S6K, and p-ULK in a dose-dependent manner.|In Vivo:|Acacetin (5, 7-Dihydroxy-4′-methoxyflavone; 5, 20 mg/kg/day; orally; for 3 days) significantly suppresses microglial activation in an LPS-induced neuroinflammation mouse model. Acacetin (25 mg/kg/day; orally; for 3 days) reduces neuronal cell death in an animal model of ischemia. Acacetin (1.8-56.2 mg/kg/day; ip; single dose) decreases visceral and inflammatory nociception and prevented the formalin-induced oedema.|References:|Hong-Wei Zhang, et al. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. Sci Rep. 2018 Jul 26;8(1):11255.Sang Keun Ha, et al. Acacetin attenuates neuroinflammation via regulation the response to LPS stimuli in vitro and in vivo. Neurochem Res. 2012 Jul;37(7):1560-7.A I Carballo-Villalobos, et al. Evidence of mechanism of action of anti-inflammatory/antinociceptive activities of acacetin. Eur J Pain. 2014 Mar;18(3):396-405.Products are for research use only. Not for human use.|
