Product Name :
A-935142
Description:
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization.
CAS:
1031335-85-9
Molecular Weight:
352.35
Formula:
C18H19F3N2O2
Chemical Name:
2-(4-{4-[5-(trifluoromethyl)-1H-pyrazol-3-yl]phenyl}cyclohexyl)acetic acid
Smiles :
OC(=O)CC1CCC(CC1)C1=CC=C(C=C1)C1C=C(NN=1)C(F)(F)F
InChiKey:
YPHFQSYEKIEMNC-UHFFFAOYSA-N
InChi :
InChI=1S/C18H19F3N2O2/c19-18(20,21)16-10-15(22-23-16)14-7-5-13(6-8-14)12-3-1-11(2-4-12)9-17(24)25/h5-8,10-12H,1-4,9H2,(H,22,23)(H,24,25)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Calcipotriol} medchemexpress|{Calcipotriol} Vitamin D Related/Nuclear Receptor|{Calcipotriol} Technical Information|{Calcipotriol} Data Sheet|{Calcipotriol} manufacturer|{Calcipotriol} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Atacicept} MedChemExpress|{Atacicept} Technical Information|{Atacicept} Purity|{Atacicept} custom synthesis|{Atacicept} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31588806
Additional information:
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. A-935142 enhances hERG current in a complex manner by facilitation of activation, reduction of inactivation, and slowing of deactivation, and abbreviates atrial and ventricular repolarization.|Product information|CAS Number: 1031335-85-9|Molecular Weight: 352.35|Formula: C18H19F3N2O2|Chemical Name: 2-(4-{4-[5-(trifluoromethyl)-1H-pyrazol-3-yl]phenyl}cyclohexyl)acetic acid|Smiles: OC(=O)CC1CCC(CC1)C1=CC=C(C=C1)C1C=C(NN=1)C(F)(F)F|InChiKey: YPHFQSYEKIEMNC-UHFFFAOYSA-N|InChi: InChI=1S/C18H19F3N2O2/c19-18(20,21)16-10-15(22-23-16)14-7-5-13(6-8-14)12-3-1-11(2-4-12)9-17(24)25/h5-8,10-12H,1-4,9H2,(H,22,23)(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|A-935142 shortens the action potential duration (APD90) in guinea pig atrial tissue and canine cardiac Purkinje fibers. A-935142 shortens cardiac action potentials and enhances the amplitude of the hERG current in a concentration- and voltage-dependent manner. A-935142 (60μM) increases both outward and inward K(+) current as well as the slope conductance of the linear portion of the fully activated I-V relation. A-935142 significantly reduces the time constants (tau) of hERG channel activation at two example voltages (-10 mV: tau=100+/-17 ms vs. 164+/-24 ms, n=6, PProducts are for research use only. Not for human use.|
