Product Name :
LP-922056
Description:
LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats.
CAS:
1365060-22-5
Molecular Weight:
300.78
Formula:
C11H9ClN2O2S2
Chemical Name:
2-({6-chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl}sulfanyl)acetic acid
Smiles :
OC(=O)CSC1=NC=NC2C(C3CC3)=C(Cl)SC=21
InChiKey:
LJYRIWUQISYYHA-UHFFFAOYSA-N
InChi :
InChI=1S/C11H9ClN2O2S2/c12-10-7(5-1-2-5)8-9(18-10)11(14-4-13-8)17-3-6(15)16/h4-5H,1-3H2,(H,15,16)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LP-922056 is an orally active, highly potent Notum Pectinacetylesterase inhibitor with EC50s of 21 nM, 55 nM in human and mouse cellular assay, respectively. LP-922056 significantly increases midshaft femur cortical bone thickness in mice and rats.|Product information|CAS Number: 1365060-22-5|Molecular Weight: 300.78|Formula: C11H9ClN2O2S2|Chemical Name: 2-({6-chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl}sulfanyl)acetic acid|Smiles: OC(=O)CSC1=NC=NC2C(C3CC3)=C(Cl)SC=21|InChiKey: LJYRIWUQISYYHA-UHFFFAOYSA-N|InChi: InChI=1S/C11H9ClN2O2S2/c12-10-7(5-1-2-5)8-9(18-10)11(14-4-13-8)17-3-6(15)16/h4-5H,1-3H2,(H,15,16)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (415.59 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Anti-Mouse 4-1BB Antibody} medchemexpress|{Anti-Mouse 4-1BB Antibody} TNF Receptor|{Anti-Mouse 4-1BB Antibody} Biological Activity|{Anti-Mouse 4-1BB Antibody} Purity|{Anti-Mouse 4-1BB Antibody} manufacturer|{Anti-Mouse 4-1BB Antibody} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{Vortioxetine} medchemexpress|{Vortioxetine} Neuronal Signaling|{Vortioxetine} Biological Activity|{Vortioxetine} Description|{Vortioxetine} supplier|{Vortioxetine} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24732841 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|NOTUM can inactivate WNTs by functioning as a WNT lipase.|In Vivo:|LP-922056 (compound 44; 3-30 mg/kg; oral gavage; daily; for 25 days) causes an increase in cortical bone thickness at all doses. LP-922056 (10 mg/kg; orally) achieves high Cmax (129 μM) and AUC (1533 μM•h). LP-922056 (10 mg/kg; daily diet; for 4 weeks) increases cortical bone thickness and strength in midshaft femur, bone mass in the femoral neck and vertebral body cortical shell in Twelve-week-old male mice.|Products are for research use only. Not for human use.|
