Product Name :
Efaproxiral sodium
Description:
Efaproxiral sodium (RSR13 sodium) is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.
CAS:
170787-99-2
Molecular Weight:
363.38
Formula:
C20H22NNaO4
Chemical Name:
sodium 2-(4-{[(3,5-dimethylphenyl)carbamoyl]methyl}phenoxy)-2-methylpropanoate
Smiles :
[Na+].CC1=CC(=CC(C)=C1)NC(=O)CC1C=CC(=CC=1)OC(C)(C)C([O-])=O
InChiKey:
SWDPIHPGORBMFR-UHFFFAOYSA-M
InChi :
InChI=1S/C20H23NO4.Na/c1-13-9-14(2)11-16(10-13)21-18(22)12-15-5-7-17(8-6-15)25-20(3,4)19(23)24;/h5-11H,12H2,1-4H3,(H,21,22)(H,23,24);/q;+1/p-1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Estetrol} web|{Estetrol} Vitamin D Related/Nuclear Receptor|{Estetrol} Biological Activity|{Estetrol} Description|{Estetrol} custom synthesis|{Estetrol} Cancer}
Shelf Life:
≥12 months if stored properly.{{TNF-α-IN-6} MedChemExpress|{TNF-α-IN-6} Inhibitor|{TNF-α-IN-6} Immunology/Inflammation|{TNF-α-IN-6} Biological Activity|{TNF-α-IN-6} In Vivo|{TNF-α-IN-6} manufacturer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:26446225
Additional information:
Efaproxiral sodium (RSR13 sodium) is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.|Product information|CAS Number: 170787-99-2|Molecular Weight: 363.38|Formula: C20H22NNaO4|Chemical Name: sodium 2-(4-{[(3,5-dimethylphenyl)carbamoyl]methyl}phenoxy)-2-methylpropanoate|Smiles: [Na+].CC1=CC(=CC(C)=C1)NC(=O)CC1C=CC(=CC=1)OC(C)(C)C([O-])=O|InChiKey: SWDPIHPGORBMFR-UHFFFAOYSA-M|InChi: InChI=1S/C20H23NO4.Na/c1-13-9-14(2)11-16(10-13)21-18(22)12-15-5-7-17(8-6-15)25-20(3,4)19(23)24;/h5-11H,12H2,1-4H3,(H,21,22)(H,23,24);/q;+1/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 39 mg/mL (107.33 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
