Product Name :
MMPI-1154
Description:
MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC50=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC50s of 1.8 μM,10 μM, and 13 μM, respectively.
CAS:
1382722-47-5
Molecular Weight:
445.49
Formula:
C26H24FN3O3
Chemical Name:
2-[({[4-(benzyloxy)phenyl]methyl}[(4-fluorophenyl)methyl]amino)methyl]-1H-imidazole-5-carboxylic acid
Smiles :
OC(=O)C1=CN=C(CN(CC2C=CC(F)=CC=2)CC2C=CC(=CC=2)OCC2C=CC=CC=2)N1
InChiKey:
QLTNFRCPUOPISS-UHFFFAOYSA-N
InChi :
InChI=1S/C26H24FN3O3/c27-22-10-6-19(7-11-22)15-30(17-25-28-14-24(29-25)26(31)32)16-20-8-12-23(13-9-20)33-18-21-4-2-1-3-5-21/h1-14H,15-18H2,(H,28,29)(H,31,32)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MMPI-1154 is a promising novel cardio-cytoprotective imidazole-carboxylic acid (ICA) MMP-2 inhibitor(IC50=6.6 μM) and can be used for the study of acute myocardial infarction. MMPI-1154 also inhibits the activity of MMP-13, MMP-1 and MMP-9 with IC50s of 1.8 μM,10 μM, and 13 μM, respectively.|Product information|CAS Number: 1382722-47-5|Molecular Weight: 445.49|Formula: C26H24FN3O3|Chemical Name: 2-[({[4-(benzyloxy)phenyl]methyl}[(4-fluorophenyl)methyl]amino)methyl]-1H-imidazole-5-carboxylic acid|Smiles: OC(=O)C1=CN=C(CN(CC2C=CC(F)=CC=2)CC2C=CC(=CC=2)OCC2C=CC=CC=2)N1|InChiKey: QLTNFRCPUOPISS-UHFFFAOYSA-N|InChi: InChI=1S/C26H24FN3O3/c27-22-10-6-19(7-11-22)15-30(17-25-28-14-24(29-25)26(31)32)16-20-8-12-23(13-9-20)33-18-21-4-2-1-3-5-21/h1-14H,15-18H2,(H,28,29)(H,31,32)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (187.{{Tesofensine} MedChemExpress|{Tesofensine} Serotonin Transporter|{Tesofensine} Technical Information|{Tesofensine} Data Sheet|{Tesofensine} manufacturer|{Tesofensine} Cancer} 05 mM; Need ultrasonic).{{E1210} site|{E1210} Fungal|{E1210} Protocol|{E1210} Purity|{E1210} manufacturer|{E1210} Cancer} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23746961 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MMPI-1154 (1-100 μM) inhibits MMP-2 enzyme isolated from rat heart in vitro, and 100% inhibition appears at the concentraction 100 μM. MMPI-1154 (1 μM) shows significant cardio-cytoprotecion, significantly decreases infarct size in an ex vivo model for acute myocardial infarction.|Products are for research use only. Not for human use.|
