Product Name :
NVP-HSP990
Description:
HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation.
CAS:
934343-74-5
Molecular Weight:
379.39
Formula:
C20H18FN5O2
Chemical Name:
(7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-5-one
Smiles :
CC1=NC(N)=NC2C[C@@H](NC(=O)C1=2)C1=CC=C(F)C=C1C1=CC=CC(=N1)OC
InChiKey:
WSMQUUGTQYPVPD-OAHLLOKOSA-N
InChi :
InChI=1S/C20H18FN5O2/c1-10-18-16(26-20(22)23-10)9-15(25-19(18)27)12-7-6-11(21)8-13(12)14-4-3-5-17(24-14)28-2/h3-8,15H,9H2,1-2H3,(H,25,27)(H2,22,23,26)/t15-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ixazomib} MedChemExpress|{Ixazomib} Proteasome|{Ixazomib} Protocol|{Ixazomib} In stock|{Ixazomib} custom synthesis|{Ixazomib} Epigenetics}
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Rilpivirine} site|{Rilpivirine} Reverse Transcriptase|{Rilpivirine} Protocol|{Rilpivirine} In Vivo|{Rilpivirine} manufacturer|{Rilpivirine} Epigenetics}
Additional information:
HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity.PMID:25046520 Hsp990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation.|Product information|CAS Number: 934343-74-5|Molecular Weight: 379.39|Formula: C20H18FN5O2|Chemical Name: (7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-5H,6H,7H,8H-pyrido[4,3-d]pyrimidin-5-one|Smiles: CC1=NC(N)=NC2C[C@@H](NC(=O)C1=2)C1=CC=C(F)C=C1C1=CC=CC(=N1)OC|InChiKey: WSMQUUGTQYPVPD-OAHLLOKOSA-N|InChi: InChI=1S/C20H18FN5O2/c1-10-18-16(26-20(22)23-10)9-15(25-19(18)27)12-7-6-11(21)8-13(12)14-4-3-5-17(24-14)28-2/h3-8,15H,9H2,1-2H3,(H,25,27)(H2,22,23,26)/t15-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
