S morhua 4,5,Cohabitation for 7 days Air exposure (3 min) Thermal shock (from 10 to

S morhua 4,5,Cohabitation for 7 days Air exposure (3 min) Thermal shock (from 10 to 15 C in 30 min) Confinement tension (i.e., lowering of water level) for 30 min7 7 72,8 0.26.62 0.four.58 0.5.3Totoaba macdonaldiHandling (chasing Activated Integrinalpha 5 beta 1 Inhibitors products having a net for 45 min) Hypoxia (1 mg oxygen L through 45 min)Dicentrarchus labrax8 Argyrosomus regiusInflammatory insult (intraperitoneal injection with an inactivated pathogen) Air exposure (three min) Confinement and netting (3 min)141.12.24 g 16 g-1 N 0.07.11Solea senegalensis10 Methionine Sparus aurataHigh m-Tolylacetic acid Purity & Documentation density (31 kgm2 ) Hypoxia (2.8 mg oxygen L during five h)390.44.05 handle; handle + 0.3 2.57.95 g 16 g-1 N Different amino acid mix Diverse amino acid mix control; control + 0.025 0.01.0 4Dicentrarchus labrax8 Synergistic effects of amino acids Solea senegalensisInflammatory insult (intraperitoneal injection with an inactivated pathogen) Repeated weekly handling (air exposure)14 14;Solea senegalensisHigh density (12 kgm2 )Vitamin CSparus aurata14 Sebastes schlegelii15,High density (12 Kgm3 ) Exposure to hexavalent chromium (i.e., 120 and 240 mgL)63 14;Vitamin ESparus aurataHigh density (12 Kgm3 )manage; control + 0.025 0.1.14 0.000230.03116Huso huso17 Takifugu obscurusNetting and air exposure (i.e., 1.5 min) Exposure to ammonia-nitrogen for 48 h (i.e., 100 mgL)48ArASparus aurata19,20,21,22,Each day salinity tension (fluctuating salinity more than 24 h, from 25 to 40 and back to 25 )20;0.059.586 reside prey DW(Continued)Frontiers in Endocrinology | www.frontiersin.orgJuly 2019 | Volume 10 | ArticleHerrera et al.Additives for Fish Strain MitigationTABLE 2 | Continued Additive Fish species Strain conditiontreatment Feeding time, days 28; 50 18 240 72 Test doses Main effects on physiology and productivity Whole-body cortisol levels Development Plasmacortisol levels Plasma cortisol levels Plasma cortisol and glucose levels Gene Expression in cell- and tissue-repairing markers, antioxidant enzymes, nuclear receptors and transcription factors expression levels of PPAR and PEPCK Expression levels of glucocorticoid receptor 1 and 2 in liver Expression level of genes associated to defensive response against virus, antigen differentiation and cytokines Final weight Gene expression of StAR and CYP11 Expression degree of genes connected to glucocorticoid receptor complex Expression levels of glucocorticoid receptor 1 and two in liver Expression degree of genes associated to defensive response against virus, antigen differentiation and cytokines Final weight Expression levels of glucocorticoid receptor 1 and two in liver Expression level of genes associated to defensive response against virus, antigen differentiation and cytokines Final weight Plasma cortisol levels in infected and stressed and infected groups Plasma cortisol levels in stressed groups Side-effects of strain on microflora profiles Plasma cortisol and glucose levels at 1 h following acute anxiety No alterations in plasma cortisol levels No effect on growth Survival immediately after air exposure No adjustments in cortisol levels HIF-2 in entire larvae GrowthAir exposure for 90 s Confinement: five in of submersion in dip-net Crowding strain (439 kgm3 ) Crowding strain (9000 kgm3 )0.15.75 Artemia DW 0.9.four 0.2.11 FA 0.13.31 TFASolea senegalensis24,25,Air exposure (two min) Chasing anxiety test consisting of five min net chasing140.1.three Artemia DW 0.5.8 TFA 0.5.eight TFADicentrarchus labraxHandling 20 larvae per tank out from the water in a scoop net for 1 min0.3- 1.2EPASolea senegalensis25,C.