Product Name: TTK Antibody#3255
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:50
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 1373615-35-0
Product: PF-5274857
Specificity Sensitivity: TTK Antibody detects endogenous levels of total TTK protein. TTK, also known as PYT (Phosphotyrosine Picked Threonine Kinase), is the human homolog of MSP1 (Monopolar Spindle 1) in budding yeast and murine ESK (Embryonal Carcinoma STY Kinase).
Species Reactivity: Human
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu137 of human TTK. Antibodies were purified by affinity chromatography.
Background: TTK (Mps1, PYT) is a cell cycle regulated dual specificity kinase present in rapidly proliferating tissues and cell lines (1-3). TTK localizes to kinetochores and centromeres and is an essential component of the mitotic spindle checkpoint as well as centr
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24692708?dopt=Abstract
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