Product Name: Phospho-Tuberin/TSC2 (Thr1462) (5B12) Rabbit mAb#3617
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:50
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 1268524-70-4
Product: (+)-JQ-1
Specificity Sensitivity: Phospho-Tuberin/TSC2 (Thr1462) (5B12) Rabbit mAb detects endogenous levels of tuberin only when phosphorylated at threonine 1462.
Species Reactivity: Human, Mouse, Rat
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr1462 of human tuberin.
Background: Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development (1). Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant d
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20427400?dopt=Abstract
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