Product Name: Phospho-IRS-1 (Ser612) Antibody#2386
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 54350-48-0
Product: Etretinate
Specificity Sensitivity: Phospho-IRS-1 (Ser612) Antibody detects endogenous IRS-1 only when phosphorylated at serine 612 of mouse IRS-1 or serine 616 of human IRS-1. The antibody does not detect IRS-1 phosphorylated at other sites.
Species Reactivity: Human, Mouse, Rat
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser612 of mouse IRS-1. Antibodies are purified by protein A and peptide affinity chromatography.
Background: Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase (1). IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and g
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23922990?dopt=Abstract
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