Product Name: Phospho-Chk1 (Ser317) (D7H2) Rabbit mAb#8191
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 179461-52-0
Product: PD 151746
Specificity Sensitivity: Phospho-Chk1 (Ser317) (D7H2) Rabbit mAb recognizes endogenous levels of Chk1 protein only when phosphorylated at Ser317.
Species Reactivity: Human
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser317 of human Chk1 protein.
Background: Chk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, embryonic development, and tumor suppression (1). Activation of Chk1 involves phosphorylation at Ser317 and Ser345 by ATM/ATR, followed by autophos
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24199968?dopt=Abstract
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