Product Name: Phospho-CENP-A (Ser7) Antibody#2187
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:25
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 415903-37-6
Product: Grapiprant
Specificity Sensitivity: Phospho-CENP-A (Ser7) Antibody detects endogenous levels of human CENP-A protein only when phosphorylated on Ser7. This antibody does not cross-react with other histone proteins, including Histone H3.
Species Reactivity: Human
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser7 of human CENP-A protein. Antibodies are purified by peptide affinity chromatography.
Background: Modulation of chromatin structure plays a critical role in the regulation of transcription and replication of the eukaryotic genome. The nucleosome, made up of four core histone proteins (H2A, H2B, H3, and H4), is the primary building block of chromatin.
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20138661?dopt=Abstract
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