Product Name: Phospho-53BP1 (Thr543) Antibody#3428
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 40077-57-4
Product: Aviptadil
Specificity Sensitivity: Phospho-53BP1 (Thr543) Antibody detects endogenous levels of 53BP1 protein only when phosphorylated at Thr543.
Species Reactivity: Human
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surounding Thr543 of human 53BP1. Antibodies are purified using protein A and peptide affinity chromatography.
Background: p53-binding protein 1 (53BP1) was originally identified as a p53 binding partner that could enhance the transcriptional activity of p53 (1,2). 53BP1 consists of two BRCA1 carboxy terminal (BRCT) domains that allow for binding to p53 and a separate domain
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24912190?dopt=Abstract
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