Product Name: Phospho-4E-BP1 (Thr70) (D7F6I) Rabbit mAb#13396
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:50
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 664969-54-4
Product: LF3
Specificity Sensitivity: Phospho-4E-BP1 (Thr70) (D7F6I) Rabbit mAb recognizes endogenous levels of 4E-BP1 protein only when phosphorylated at Ser70.
Species Reactivity: Human, Monkey
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr70 of human 4E-BP1 protein.
Background: Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent trans
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/28188211?dopt=Abstract
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