Product Name: Notch Isoform Antibody Sampler Kit#3640
Application:
Western Blotting:
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage:
CAS NO.: 195199-04-3
Product: Dye 937
Specificity Sensitivity: Cleaved Notch1 (V1744) (D3B8) Rabbit mAb detects endogenous levels of the Notch1 intra- cellular domain (NICD) only when released by cleavage between Gly1753 and Val1754 (equivalent to Gly1743/Val1744 of murine notch1). The antibody does not recognize ful
Species Reactivity:
Source Purification: Monoclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence at the Val1754 cleavage site in human Notch1 (equivalent to Val1744 in mouse Notch1), Pro2438 of human Notch1, Ala2738 of human Notch2, or Glu2
Background: Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate (1). Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20837520?dopt=Abstract
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