Product Name: K48-linkage Specific Polyubiquitin Antibody#4289
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 71610-00-9
Product: Cephalomannine
Specificity Sensitivity: K48-linkage Specific Polyubiquitin Antibody detects polyubiquitin chains formed by Lys48 residue linkage. Antibody demonstrates slight cross-reactivity with linear polyubiquitin chain. No cross-reactivity observed with monoubiquitin or polyubiquitin chain
Species Reactivity: Human, All Species Expected
Source Purification: Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the Lys48 branch the human diubiquitin chain. Antibodies are purified by protein A and peptide affinity chromatography.
Background: Ubiquitin is a conserved polypeptide unit that plays an important role in the ubiquitin-proteasome pathway. Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S prote
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/24512807?dopt=Abstract
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