Product Name: Cleaved Caspase-8 (Asp387) (D5B2) XP® Rabbit mAb (Mouse Specific)#8592
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:100
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 120876-23-5
Product: Protirelin (Acetate)
Specificity Sensitivity: Cleaved Caspase-8 (Asp387) (D5B2) XP® Rabbit mAb (Mouse Specific) recognizes endogenous levels of mouse caspase-8 only when cleaved at Asp387. In addition to the p18 subunit, this antibody also detects cleavage products containing the pro-domain with the
Species Reactivity: Mouse
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp387 of mouse caspase-8 protein.
Background: Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream ef
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/23349461?dopt=Abstract
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