Product Name: Caspase-8 (D35G2) Rabbit mAb#4790
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 1801747-11-4
Product: SHP099 (hydrochloride)
Specificity Sensitivity: Caspase-8 (D35G2) Rabbit mAb detects endogenous levels of total caspase-8, including the p10 subunit of the activated protein. Caspase-8 (D35G2) Rabbit mAb may also cross-react with overexpressed levels of caspase-10.
Species Reactivity: Human, Mouse, Rat
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxyl terminus of human caspase-8 protein.
Background: Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream ef
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19773260?dopt=Abstract
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