Product Name: Caspase-2 (C2) Mouse mAb#2224
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation:
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 248919-64-4
Product: AZD0865
Specificity Sensitivity: Caspase-2 (C2) Mouse mAb detects endogenous levels of procaspase-2 as well as its 14 and 12 kDa cleaved fragments.
Species Reactivity: Human
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the carboxy-terminal portion of human caspase-2.
Background: Caspase-2 (Nedd2/ICH-1) is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved at Asp316, producing a 14 kDa fragment and a 32 kDa prodomain/large subunit. Subsequ
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26678887?dopt=Abstract
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