Product Name: β-Arrestin 1 (D8O3J) Rabbit mAb#12697
Application: Dilutions
Western Blotting: 1:1000
Immunoprecipitation: 1:200
Immunohistochemistry:
Peptide ELISA:
Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
CAS NO.: 1224887-10-8
Product: GSK2256098
Specificity Sensitivity: β-arrestin 1 (D8O3J) Rabbit mAb recognizes endogenous levels of total β-arrestin 1 protein. This antibody does not cross-react with β-arrestin 2.
Species Reactivity: Human, Mouse, Rat, Monkey
Source Purification: Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human β-arrestin 1 protein.
Background: Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization
PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/17991446?dopt=Abstract
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